References

  1. Y.L. Luo, W.S. Guo, H.H. Ngo, L.D. Nghiem, F.I. Hai, J. Zhang, S. Liang, X.C. Wang, A review on the occurrence of micropollutants in the aquatic environment and their fate and removal during wastewater treatment, Sci. Total Environ., 473–474 (3) (2014) 619–641.
  2. E.R. Kabir, M.S. Rahman, I. Rahman, A review on endocrine disruptors and their possible impacts on human health, Environ. Toxicol. Phar., 40(1) (2015) 241–258.
  3. D.G.S. Ortiz, P.A. García-Encina, R. Irusta-Mata, The potential ecotoxicological impact of pharmaceutical and personal care products on humans and freshwater, based on usetox™ characterization factors. a spanish case study of toxicity impact scores, Sci. Total Environ., 609 (2017) 429–445.
  4. H. Fang, L. Han, H. Zhang, Z. Long, L. Cai, Y. Yu, Dissemination of antibiotic resistance genes and human pathogenic bacteria from a pig feedlot to the surrounding stream and agricultural soils, J. Hazard. Mater., 357 (2018) 53–62.
  5. C.E. Gökçe, S. Güneysu, S. Arayici, Evaluation of estrogenic hormones in water reservoirs and municipality treatment plants in Istanbul, Desal. Water Treat., 93 (2017) 329–334.
  6. M. Giulivo, D.A.M. Lopez, E. Capri, D. Barcelã, Human exposure to endocrine disrupting compounds: their role in reproductive systems, metabolic syndrome and breast cancer. a review, Environ. Res., 151 (2016) 251–264.
  7. A.T. Lebedev, O.V. Polyakova, D.M. Mazur, V.B. Artaev, I. Canet, A. Lallement, Detection of semi-volatile compounds in cloud waters by gc×gc-tof-ms, evidence of phenols and phthalates as priority pollutants, Environ. Pollut., 241 (2018) 616–625.
  8. Commission of the European Communities, Commission Staff Working Document on the Implementation of the Community Strategy for Endocrine Disrupters: A Range of Substances Suspected of Interfering with the Hormone Systems of Humans and Wildlife. Brussels, 2007.
  9. H. Liu, J.C.W. Lam, W.W. Li, H.Q. Yu, P.K.S. Lam, Spatial distribution and removal performance of pharmaceuticals in municipal wastewater treatment plants in China, Sci. Total Environ., 586 (2017) 1162–1169.
  10. J.L. Liu, M.H. Wong, Pharmaceuticals and personal care products (PPCPS): a review on environmental contamination in China, Environ. Int., 59(3) (2013) 208–224.
  11. S. Park, W. Lee, Occurrence and removal of contaminants of emerging concern in water reclamation facilities in Korea, Desal. Water Treat., 95 (2017) 109–117.
  12. J. Campo, A. Masiá, C. Blasco, Y. Picó, Occurrence and removal efficiency of pesticides in sewage treatment plants of four Mediterranean river basins, J. Hazard. Mater., 263 (2013) 146–157.
  13. B.C Tran, M.J. Teil, M. Blanchard, F. Alliot, M. Chevreuil, BPA and phthalate fate in a sewage network and an elementary river of France. influence of hydroclimatic conditions, Chemosphere, 119 (2015) 43–51.
  14. N.A. Al-Odaini, M.P. Zakaria, M.I. Yaziz, S. Surif, M. Abdulghani, The occurrence of human pharmaceuticals in wastewater effluents and surface water of Langat river and its tributaries, Malaysia, Int. J. Environ. Anal. Chem., 93(3) (2013) 245–264.
  15. S.K. Behera, H.W. Kim, J.E. Oh, H.S. Park, Occurrence and removal of antibiotics, hormones and several other pharmaceuticals in wastewater treatment plants of the largest industrial city of Korea, Sci. Total Environ., 409(20) (2011) 4351–4360.
  16. K.J. Choi, S.G. Kim, S.H. Kim, Removal of antibiotics by coagulation and granular activated carbon filtration, J. Hazard. Mater., 151(1) (2008) 38–43.
  17. E. Gracia-Lor, J.V. Sancho, R. Serrano, F. Hernández, Occurrence and removal of pharmaceuticals in wastewater treatment plants at the Spanish Mediterranean area of Valencia, Chemosphere, 87(5) (2012) 453–462.
  18. B. Kasprzyk-Hordern, R.M. Dinsdale, A.J. Guwy, The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters, Water Res., 43(2) (2009) 363–380.
  19. B. Kasprzyk-Hordern, R.M. Dinsdale, A.J. Guwy, Multiresidue methods for the analysis of pharmaceuticals, personal care products and illicit drugs in surface water and wastewater by solid-phase extraction and ultra performance liquid chromatography-electrospray tandem mass spectrometry, Anal. Bioanal. Chem., 391(4) (2008) 1293–1308.
  20. B. Petrie, R. Barden, B. Kasprzykhordern, A review on emerging contaminants in wastewaters and the environment: current knowledge, understudied areas and recommendations for future monitoring, Water Res., 72 (2015) 3–27.
  21. J.L. Santos, I. Aparicio, M. Callejón, E. Alonso, Occurrence of pharmaceutically active compounds during 1-year period in wastewaters from four wastewater treatment plants in Seville (Spain), J. Hazard Mater., 164(2–3) (2009) 1509–1516.
  22. S. Terzić, I. Senta, M. Ahel, M. Gros, M. Petrović, D. Barcelo, Occurrence and fate of emerging wastewater contaminants in western Balkan region, Sci. Total Environ., 399(1) (2008) 66–77.
  23. M. Gardner, S. Comber, M.D. Scrimshaw, E. Cartmell, J. Lester, B. Ellor, The significance of hazardous chemicals in wastewater treatment works effluents, Sci. Total Environ., 437(3) (2012) 363–372.
  24. R. Loos, R. Carvalho, D.C. António, S. Comero, G. Locoro, S. Tavazzi, EU-wide monitoring survey on emerging polar organic contaminants in wastewater treatment plant effluents, Water Res., 4(17) (2013) 6475–6487.
  25. N. Stamatis, D. Hela, I. Konstantinou, Occurrence and removal of fungicides in municipal sewage treatment plant, J. Hazard Mater., 175 (2010) 829–835.
  26. H. Zhou, C. Wu, X. Huang, M. Gao, X. Wen, H. Tsuno, Occurrence of selected pharmaceuticals and caffeine in sewage treatment plants and receiving rivers in Beijing, China, Water Environ. Res., 82(11) (2010) 2239–2248.
  27. S. Zorita, L. Mårtensson, L. Mathiasson, Occurrence and removal of pharmaceuticals in a municipal sewage treatment system in the south of Sweden, Sci. Total Environ., 407(8) (2009) 2760–2770.
  28. H. Singer, S. Jaus, I. Hanke, A. Lück, J. Hollender, A.C. Alder, Determination of biocides and pesticides by on-line solid phase extraction coupled with mass spectrometry and their behaviour in wastewater and surface water, Environ. Pollut., 158(10) (2010) 3054–3064.
  29. C.P. Yu, K.H. Chu, Occurrence of pharmaceuticals and personal care products along the west prong little pigeon river in east Tennessee, USA, Chemosphere, 75(10) (2009) 1281–1286.
  30. R. Guedes-Alonso, C. Afonso-Olivares, S. Montesdeoca-Esponda, Z. Sosa-Ferrera, J.J. Santana-Rodríguez, An assessment of the concentrations of pharmaceutical compounds in wastewater treatment plants on the island of gran Canaria (Spain), Springer plus, 2(1) (2013) 1–8.
  31. Z. Wang, X.H. Zhang, Y. Huang, H. Wang, Comprehensive evaluation of pharmaceuticals and personal care products (PPCPs) in typical highly urbanized regions across China, Environ. Pollut., 204 (2015) 223–232.
  32. L. Gao, Y. Shi, W. Li, H. Niu, J. Liu, Y. Cai, Occurrence of antibiotics in eight sewage treatment plants in Beijing, China, Chemosphere, 86(6) (2012) 665–671.
  33. M.H. Wu, C.J. Que, G. Xu, Y.F. Sun, J. Ma, H. Xu, Occurrence, fate and interrelation of selected antibiotics in sewage treatment plants and their receiving surface water, Ecotoxicol. Environ. Safe., 132 (2016) 132–139.
  34. W. Li, Y. Shi, L. Gao, J. Liu, Y. Cai, Occurrence and removal of antibiotics in a municipal wastewater reclamation plant in Beijing, China, Chemosphere, 92(4) (2013) 435–444.
  35. R.S. Martin, M. Esperanza, J. Choubert, I. Valor, H. Budzinski, M. Coquery, On-site evaluation of the efficiency of conventional and advanced secondary processes for the removal of 60 organic micropollutants, Water Sci. Technol., 62 (2010) 2970–2978.
  36. A.C. Alder, C. Schaffner, M. Majewsky, J. Klasmeier, K. Fenner, Fate of beta-blocker human pharmaceuticals in surface water: comparison of measured and simulated concentrations in the Glatt valley watershed, Switzerland, Water Res., 44(3) (2010) 936–948.
  37. P. Pothitou, D. Voutsa, Endocrine disrupting compounds in municipal and industrial wastewater treatment plants in northern Greece, Chemosphere, 73(11) (2008) 1716–1723.
  38. M.L. Janex-Habibi, A. Huyard, M. Esperanza, A. Bruchet, Reduction of endocrine disruptor emissions in the environment: the benefit of wastewater treatment, Water Res., 43(6) (2009) 1565–1576.
  39. Y. Nie, Z. Qiang, H. Zhang, W. Ben, Fate and seasonal variation of endocrine-disrupting chemicals in a sewage treatment plant with A/A/O process, Sep. Purif. Technol., 84(1) (2012) 9–15.
  40. A. Vallejo, A. Prieto, M. Moeder, A. Usobiaga, O. Zuloaga, N. Etxebarria, Calibration and field test of the polar organic chemical integrative samplers for the determination of 15 endocrine disrupting compounds in wastewater and river water with special focus on performance reference compounds (prc), Water Res., 47(8) (2013) 2851–2862.
  41. M. Clara, G. Windhofer, W. Hartl, K. Braun, M. Simon, O. Gans, Occurrence of phthalates in surface runoff, untreated and treated wastewater and fate during wastewater treatment, Chemosphere, 78(9) (2010) 1078–1084.
  42. D. Gao, Z. Li, Z. Wen, N. Ren, Occurrence and fate of phthalate esters in full-scale domestic wastewater treatment plants and their impact on receiving waters along the Songhua river in China, Chemosphere, 95(1) (2014) 24–32.
  43. S. Net, R. Sempéré, A. Delmont, A. Paluselli, B. Ouddane, Occurrence, fate, behavior and ecotoxicological state of phthalates in different environmental matrices, Environ. Sci. Technol., 49(7) (2015) 4019–4035.
  44. EPA Method 1694, Pharmaceuticals and personal care products in water, soil, sediment, and biosolids by HPLC/MS/MS, EPA Document No. EPA-821-R-08-002, 2007.
  45. EPA Method 539, Determination of hormones in drinking water by solid phase extraction (SPE) and liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS), EPA Document No. 815-B-10-001, 2010.
  46. Q. Chen, J. Shi, W. Wu, X. Liu, H. Zhang, A new pretreatment and improved method for determination of selected estrogens in high matrix solid sewage samples by liquid chromatography mass spectrometry, Microchem. J., 104 (2012) 49–55.
  47. EPA Method 8270D, Semivolatile organic compounds by gas chromatography/mass spectrometry (GC/MS), Revision 4, 2007.
  48. APHA, AWWA, WEF. Standard Methods for the Examination of Water and Wastewater, 22nd ed., Washington, DC, 1995.
  49. European Commission, Technical Guidance Document on Risk Assessment, 2003, http://europa.eu.int.
  50. K. Eguchi, H. Nagase, M. Ozawa, Y.S. Endoh, K. Goto, K. Hirata, K. Miyamoto, H. Yoshimura, Evaluation of antimicrobial agents for veterinary use in the ecotoxicity test using microalgae, Chemosphere, 57(11) (2004) 1733–1738.
  51. C. Saejung, K. Hatai, L.O. Sanoamuang, Bath efficacy of sodium hypochlorite, oxytetracycline dihydrate and chloramphenicol against bacterial black disease in fairy shrimp Branchinella thailandensis, Aquac. Res., 45(10) (2014) 1697–1705.
  52. Q. Bu, B. Wang, J. Huang, S. Deng, G. Yu, Pharmaceuticals and personal care products in the aquatic environment in China: a review, J. Hazard. Mater., 262(22) (2013) 189–211.
  53. T. Ando, H. Nagase, K. Eguchi, T. Hirooka, T. Nakamura, K. Miyamoto, A novel method using cyanobacteria for ecotoxicity test of veterinary antimicrobial agents, Environ. Toxicol. Chem., 26(4) (2010) 601–606.
  54. Q.X. Zhou, L. Yi, Environmental residues and ecotoxicity of antibiotics and their resistance gene pollution: a review, Asian J. Ecotoxicol., 2(3) (2007) 243–251.
  55. J.W. Kim, H. Ishibashi, R. Yamauchi, N. Ichikawa, Y. Takao, M. Hirano, Acute toxicity of pharmaceutical and personal care products on freshwater crustacean (Thamnocephalus platyurus) and fish (Oryzias latipes), J. Toxicol. Sci., 34(2) (2009) 227–232.
  56. T.J. Runnalls, D.N. Hala, J.P. Sumpter, Preliminary studies into the effects of the human pharmaceutical clofibric acid on sperm parameters in adult fathead minnow, Aqua. Toxicol., 84(1) (2007) 111–118.
  57. B. Quinn, F. Gagné, C. Blaise, An investigation into the acute and chronic toxicity of eleven pharmaceuticals (and their solvents) found in wastewater effluent on the cnidarian, hydra attenuata, Sci. Total Environ., 389(2–3) (2008) 306–314.
  58. R. Rosal, I. Rodeapalomares, K. Boltes, F. Fernándezpiñas, F. Leganés, S. Gonzalo, A. Petre, Ecotoxicity assessment of lipid regulators in water and biologically treated wastewater using three aquatic organisms, Environ. Sci. Pollut. Res., 17(1) (2010) 135–144.
  59. B. Ferrari, R. Mons, B. Vollat, B. Fraysse, N. Paxēaus, R.L. Giudice, Environmental risk assessment of six human pharmaceuticals: are the current environmental risk assessment procedures sufficient for the protection of the aquatic environment, Environ. Toxicol. Chem., 23(5) (2004) 1344–1353.
  60. M. Cleuvers, Initial risk assessment for three beta-blockers found in the aquatic environment, Chemosphere, 59(2) (2005) 199–205.
  61. J. Schwaiger, H. Ferling, U. Mallow, H. Wintermayr, R.D. Negele, Toxic effects of the non-steroidal anti-inflammatory drug diclofenac. Part I: histopathological alterations and bioaccumulation in rainbow trout, Aqua. Toxicol., 68(2) (2004) 141–150.
  62. W. Jaser, G.F. Severin, U. Jütting, Effects of 17α-ethinylestradiol on the reproduction of the cladoceran species Ceriodaphnia reticulata and Sida crystallina, Environ. Int., 28(7) (2003) 633–638.
  63. C.M. Mack, B.J. Lin, J.D. Turner, A.F.M. Johnstone, L.D. Burgoon, T.J. Shafer, Burst and principal components analyses of mea data for 16 chemicals describe at least three effects classes, Neurotoxicology, 40(1) (2014) 75–85.
  64. Y.P. Chin, G. Aiken, E. O’Loughlin, Molecular weight, polydispersity, and spectroscopic properties of aquatic humic substances. Environ. Sci. Technol., 28(11) (1994) 1853–1858.
  65. J.L. Weishaar, G.R. Aiken, B.A. Bergamaschi, M.S. Fram, R. Fujii, K. Mopper, Evaluation of specific ultraviolet absorbance as an indicator of the chemical composition and reactivity of dissolved organic carbon, Environ. Sci. Technol., 37(20) (2003) 4702–4708.
  66. A. Imai, T. Fukushima, K. Matsushige, Y.H. Kim, K. Choi, Characterization of dissolved organic matter in effluents from wastewater treatment plants, Water Res., 36(4) (2002) 859–870.
  67. E. Pehlivanoglu-Mantas, D.L. Sedlak, Measurement of dissolved organic nitrogen forms in wastewater effluents: concentrations, size distribution and ndma formation potential, Water Res., 42(14) (2008) 3890–3898.
  68. N.K. Stamatis, I.K. Konstantinou, Occurrence and removal of emerging pharmaceutical, personal care compounds and caffeine tracer in municipal sewage treatment plant in western Greece, J. Environ. Sci., 48(9) (2013) 800–813.
  69. Z. Tian, Y. Zhang, H. Yuan, Y. Huo, M. Yang, F. Tang, Application of automated identification and quantification system with a database (AIQS-DB) to evaluate removal efficiency of organic micropollutants by two wastewater reclamation processes, Chinese J. Environ. Eng., 8(7) (2014) 2677–2684.
  70. J. Gao, J. Huang, W. Chen, B. Wang, Y. Wang, S. Deng, Fate and removal of typical pharmaceutical and personal care products in a wastewater treatment plant from Beijing: a mass balance study, Front. Environ. Sci. Eng. in China (English edition), 10(3) (2016) 491–501.
  71. M. Aukidy, P. Verlicchi, A. Jelic, M. Petrovic, D. Barcelo, Monitoring release of pharmaceutical compounds: occurrence and environmental risk assessment of two WWTP effluents and their receiving bodies in the Po Valley, Italy, Sci. Total Environ., 438 (2012) 15–25.
  72. R. Ke, Y. Jiang, Q. Huang, L. Chen, Investigative screening of pharmaceuticals in a municipal wastewater treatment plant in Shanghai, Asian J. Ecotoxicol., 9(6) (2014) 1146–1155.
  73. H. Zhang, M. Du, H. Jiang, D. Zhang, L. Lin, H. Ye, Occurrence, seasonal variation and removal efficiency of antibiotics and their metabolites in wastewater treatment plants, Jiulongjiang river basin, south China, Environ. Sci. Proc. Impacts, 17(1) (2014) 225–234.
  74. H. Fromme, T. Küchler, T. Otto, K. Pilz, J. Müller, A. Wenzel, Occurrence of phthalates and bisphenol A and F in the environment, Water Res., 36(6) (2002) 1429–1438.
  75. Y. Wang, Y. Li, A. Hua, A. Rashid, M. Ashfaq, Y. Wang, Monitoring, mass balance and fate of pharmaceuticals and personal care products in seven wastewater treatment plants in Xiamen City, China, J. Hazard. Mater., 354 (2018) 81–90.
  76. M.D. Hernando, M. Mezcua, A.R. Fernández-Alba, D. Barceló, Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments, Talanta, 69(2) (2006) 334–342.
  77. M. Papageorgiou, C. Kosma, D. Lambropoulou, Seasonal occurrence, removal, mass loading and environmental risk assessment of 55 pharmaceuticals and personal care products in a municipal wastewater treatment plant in central Greece, Sci. Total Environ., 543 (2016) 547–569.
  78. T. Qureshi, N. Memon, S.Q. Memon, Decontamination of ofloxacin: optimization of removal process onto sawdust using response surface methodology, Desal. Water Treat., 57(1) (2016) 221–229.
  79. R. Ma, B. Wang, L. Yin, Characterization of pharmaceutically active compounds in Beijing, China: Occurrence pattern, spatiotemporal distribution and its environmental implication, J. Hazard. Mater., 323 (2017) 147–155.