1. Y. Yang, Y.S. Ok, K.H. Kim, E.E. Kwon, Y.F. Tsang, Occurrences and removal of pharmaceuticals and personal care products (PPCPs) in drinking water and water/sewage treatment plants: a review, Sci. Total Environ., 596–597 (2017) 303–320.
  2. B. Tiwari, B. Sellamuthu, Y. Ouarda, P. Drogui, R.D. Tyagi, G. Buelna, Review on fate and mechanism of removal of pharmaceutical pollutants from wastewater using biological approach, Bioresour. Technol., 224 (2017) 1–12.
  3. Q. Sui, B. Wang, W. Zhao, J. Huang, G. Yu, S. Deng, Z. Qiu, S. Lu, Identification of priority pharmaceuticals in the water environment of China, Chemosphere, 89 (2012) 280–286.
  4. Y. Li, L. Zhang, X. Liu, J. Ding, Ranking and prioritizing pharmaceuticals in the aquatic environment of China, Sci. Total Environ., 658 (2019) 333–342.
  5. X. Yu, Q. Sui, S. Lyu, W. Zhao, J. Liu, Z. Cai, G. Yu, D. Barcelo, Municipal solid waste landfills: an underestimated source of pharmaceutical and personal care products in the water environment, Environ. Sci. Technol., 54 (2020) 9757–9768.
  6. Y. Wang, J. Liu, D. Kang, C. Wu, Y. Wu, Removal of pharmaceuticals and personal care products from wastewater using algae-based technologies: a review, Rev. Environ. Sci. Biotechnol., 16 (2017) 717–735.
  7. L.L. de Oliveira, S.C. Antunes, F. Goncalves, O. Rocha, B. Nunes, Acute and chronic ecotoxicological effects of four pharmaceuticals drugs on cladoceran Daphnia magna, Drug Chem. Toxicol., 39 (2016) 13–21.
  8. L.L. Damasceno de Oliveira, B. Nunes, S.C. Antunes, R. Campitelli-Ramos, O. Rocha, Acute and chronic effects of three pharmaceutical drugs on the tropical freshwater cladoceran Ceriodaphnia silvestrii, Water Air Soil Pollut., 229 (2018) 116, doi: 10.1007/s11270-018-3765-6.
  9. C. He, H. Wan, Drug metabolism and metabolite safety assessment in drug discovery and development, Expert Opin. Drug Metab. Toxicol., 14 (2018) 1071–1085.
  10. R. Bade, J.M. White, C. Gerber, Qualitative and quantitative temporal analysis of licit and illicit drugs in wastewater in Australia using liquid chromatography coupled to mass spectrometry, Anal. Bioanal. Chem., 410 (2018) 529–542.
  11. J.A. Baz-Lomba, M.J. Reid, K.V. Thomas, Target and suspect screening of psychoactive substances in sewage-based samples by UHPLC-QTOF, Anal. Chim. Acta, 914 (2016) 81–90.
  12. E.N. Evgenidou, I.K. Konstantinou, D.A. Lambropoulou, Occurrence and removal of transformation products of PPCPs and illicit drugs in wastewaters: a review, Sci. Total Environ., 505 (2015) 905–926.
  13. E. Partridge, S. Trobbiani, P. Stockham, T. Scott, C. Kostakis, A validated method for the screening of 320 forensically significant compounds in blood by LC/QTOF, with simultaneous quantification of selected compounds, J. Anal. Toxicol., 42 (2018) 220–231.
  14. N.K. Khalid, D. Devadasan, U.K. Aravind, C.T. Aravindakumar, Screening and quantification of emerging contaminants in Periyar River, Kerala (India) by using high-resolution mass spectrometry (LC-Q-ToF-MS), Environ. Monit. Assess., 190 (2018) 370.
  15. J. Acena, S. Stampachiacchiere, S. Perez, D. Barcelo, Advances in liquid chromatography-high-resolution mass spectrometry for quantitative and qualitative environmental analysis, Anal. Bioanal. Chem., 407 (2015) 6289–6299.
  16. S. Herrera-Lopez, M.D. Hernando, E. García-Calvo, A.R. Fernández-Alba, M.M. Ulaszewska, Simultaneous screening of targeted and non-targeted contaminants using an LC-QTOF-MS system and automated MS/MS library searching, J. Mass Spectrom., 49 (2014) 878–893.
  17. M. Ibanez, V. Borova, C. Boix, R. Aalizadeh, R. Bade, N.S. Thomaidis, F. Hernandez, UHPLC-QTOF MS screening of pharmaceuticals and their metabolites in treated wastewater samples from Athens, J. Hazard. Mater., 323 (2017) 26–35.
  18. M.J. Martinez Bueno, M.M. Ulaszewska, M.J. Gomez, M.D. Hernando, A.R. Fernandez-Alba, Simultaneous measurement in mass and mass/mass mode for accurate qualitative and quantitative screening analysis of pharmaceuticals in river water, J. Chromatogr. A, 1256 (2012) 80–88.
  19. X. Wang, N. Yu, J. Yang, L. Jin, H. Guo, W. Shi, X. Zhang, L. Yang, H. Yu, S. Wei, Suspect and non-target screening of pesticides and pharmaceuticals transformation products in wastewater using QTOF-MS, Environ. Int., 137 (2020) 105599, doi: 10.1016/j.envint.2020.105599.
  20. J.B. Arsand, R.B. Hoff, L. Jank, A. Dallegrave, C. Galeazzi, F. Barreto, T.M. Pizzolato, Wide-scope determination of pharmaceuticals and pesticides in water samples: qualitative and confirmatory screening method using LC-qTOF-MS, Water Air Soil Pollut., 229 (2018) 399, doi: 10.1007/s11270-018-4036-2.
  21. C. Boix, M. Ibanez, J.V. Sancho, J.R. Parsons, P. Voogt, F. Hernandez, Biotransformation of pharmaceuticals in surface water and during waste water treatment: identification and occurrence of transformation products, J. Hazard. Mater., 302 (2016) 175–187.
  22. F. Hernandez, M. Ibanez, E. Gracia-Lor, J.V. Sancho, Retrospective LC-QTOF-MS analysis searching for pharmaceutical metabolites in urban wastewater, J. Sep. Sci., 34 (2011) 3517–3526.
  23. M.C. Campos-Manas, I. Ferrer, E.M. Thurman, J.A. Sanchez Perez, A. Aguera, Identification of opioids in surface and wastewaters by LC/QTOF-MS using retrospective data analysis, Sci. Total Environ., 664 (2019) 874–884.
  24. J.H. Writer, I. Ferrer, L.B. Barber, E.M. Thurman, Widespread occurrence of neuro-active pharmaceuticals and metabolites in 24 Minnesota rivers and wastewaters, Sci. Total Environ., 461–462 (2013) 519–527.
  25. H.Q. Liu, J.C.W. Lam, W.W. Li, H.Q. Yu, P.K.S. Lam, Spatial distribution and removal performance of pharmaceuticals in municipal wastewater treatment plants in China, Sci. Total Environ., 586 (2017) 1162–1169.
  26. Y. Zhang, B. Wang, G. Cagnetta, L. Duan, J. Yang, S. Deng, J. Huang, Y. Wang, G. Yu, Typical pharmaceuticals in major WWTPs in Beijing, China: occurrence, load pattern and calculation reliability, Water Res., 140 (2018) 291–300.
  27. D.-H.D. Yang, M.A. Murphy, Y. Song, J. Chan, Sensitive Screening of Pharmaceuticals and Personal Care Products (PPCPs) in Water Using an Agilent 6545 Q-TOF LC/MS System, Agilent Technologies, the USA, 2015.
  28. F. Hernandez, J. Bakker, L. Bijlsma, J. de Boer, A.M. Botero- Coy, Y. Bruinen de Bruin, S. Fischer, J. Hollender, B. Kasprzyk- Hordern, M. Lamoree, F.J. Lopez, T.L.T. Laak, J.A. van Leerdam, J.V. Sancho, E.L. Schymanski, P. de Voogt, E.A. Hogendoorn, The role of analytical chemistry in exposure science: focus on the aquatic environment, Chemosphere, 222 (2019) 564–583.
  29. K.M. Blum, C. Gallampois, P.L. Andersson, G. Renman, A. Renman, P. Haglund, Comprehensive assessment of organic contaminant removal from on-site sewage treatment facility effluent by char-fortified filter beds, J. Hazard. Mater., 361 (2019) 111–122.
  30. E. Parry, T.M. Young, Comparing targeted and non-targeted high-resolution mass spectrometric approaches for assessing advanced oxidation reactor performance, Water Res., 104 (2016) 72–81.
  31. A.B. Martínez-Piernas, S. Nahim-Granados, M.I. Polo-López, P. Fernández-Ibáñez, S. Murgolo, G. Mascolo, A. Agüera, Identification of transformation products of carbamazepine in lettuce crops irrigated with Ultraviolet-C treated water, Environ. Pollut., 247 (2019) 1009–1019.
  32. E.L. Schymanski, J. Jeon, R. Gulde, K. Fenner, M. Ruff, H.P. Singer, J. Hollender, Identifying small molecules via high resolution mass spectrometry: communicating confidence, Environ. Sci. Technol., 48 (2014) 2097–2098.
  33. M. Papageorgiou, C. Kosma, D. Lambropoulou, Seasonal occurrence, removal, mass loading and environmental risk assessment of 55 pharmaceuticals and personal care products in a municipal wastewater treatment plant in Central Greece, Sci. Total Environ., 543 (2016) 547–569.
  34. Y. Luo, W. Guo, H.H. Ngo, L.D. Nghiem, F.I. Hai, J. Zhang, S. Liang, X.C. Wang, A review on the occurrence of micropollutants in the aquatic environment and their fate and removal during wastewater treatment, Sci. Total Environ., 473–474 (2014) 619–641.
  35. P. Gao, Y. Ding, H. Li, I. Xagoraraki, Occurrence of pharmaceuticals in a municipal wastewater treatment plant: mass balance and removal processes, Chemosphere, 88 (2012) 17–24.
  36. E. Vulliet, C. Cren-Olive, Screening of pharmaceuticals and hormones at the regional scale, in surface and groundwaters intended to human consumption, Environ. Pollut., 159 (2011) 2929–2934.
  37. T. Alvarino, S. Suarez, J.M. Lema, F. Omil, Understanding the removal mechanisms of PPCPs and the influence of main technological parameters in anaerobic UASB and aerobic CAS reactors, J. Hazard. Mater., 278 (2014) 506–513.
  38. X. Zhu, Y. Chen, R. Subramanian, Comparison of informationdependent acquisition, SWATH, and MSAll techniques in metabolite identification study employing ultrahighperformance liquid chromatography–quadrupole time-of-flight mass spectrometry, Anal. Chem., 86 (2014) 1202–1209.
  39. P. Gago-Ferrero, A.A. Bletsou, D.E. Damalas, R. Aalizadeh, N.A. Alygizakis, H.P. Singer, J. Hollender, N.S. Thomaidis, Wide-scope target screening of >2000 emerging contaminants in wastewater samples with UPLC-Q-ToF-HRMS/MS and smart evaluation of its performance through the validation of 195 selected representative analytes, J. Hazard. Mater., 387 (2020) 121712, doi: 10.1016/j.jhazmat.2019.121712.
  40. M. Čizmić, S. Babić, M. Kaštelan-Macan, Multi-class determination of pharmaceuticals in wastewaters by solidphase extraction and liquid chromatography tandem mass spectrometry with matrix effect study, Environ. Sci. Pollut. Res., 24 (2017) 20521–20539.
  41. E.B. Estrada-Arriaga, J.E. Cortés-Muñoz, A. González-Herrera, C.G. Calderón-Mólgora, M. de Lourdes Rivera-Huerta, E. Ramírez-Camperos, L. Montellano-Palacios, S.L. Gelover-Santiago, S. Pérez-Castrejón, L. Cardoso-Vigueros, A. Martín-Domínguez, L. García-Sánchez, Assessment of full-scale biological nutrient removal systems upgraded with physicochemical processes for the removal of emerging pollutants present in wastewaters from Mexico, Sci. Total Environ., 571 (2016) 1172–1182.
  42. C. Chan, D. Jin, N. Dong, S. Chen, D.K.W. Mok, Qualitative and quantitative analysis of chemical constituents of Centipeda minima by HPLC-QTOF-MS & HPLC-DAD, J. Pharm. Biomed., 125 (2016) 400–407.
  43. N.H. Tran, M. Reinhard, K.Y. Gin, Occurrence and fate of emerging contaminants in municipal wastewater treatment plants from different geographical regions-a review, Water Res., 133 (2018) 182–207.